Hypoglycaemia; cholestatic jaundice; agranulocytosis; aplastic anaemia; haemolytic anaemia. Blood dyscrasias (reversible), liver dysfunction, hypoglycaemia, GI symptoms, allergic skin reactions. Metformin: Lactic acidosis with alcohol and potentiation of hypoglycaemia. Cimetidine and furosemide may increase plasma-metformin levels.
Patients with severe or life-threatening hyperglycaemia, liver diseases, renal failure, ketoacidosis, pre-coma and diabetic coma, adrenocortical insufficiency, Pregnancy and lactation, Hypersensitivity, cardiac failure, recent MI, IDDM, severe infectio, severe thyroid impairment , dehydration, acute or chronic alcoholism.
Follow all exercise and dietary recommendations made by your doctor or dietitian,inform your doctor if you are about to have major surgery or develop a fever or severe infection.
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