Severe or life-threatening hyperglycaemia, liver disease,severe renal failure, juvenile diabetes, ketoacidosis, pre-coma and diabetic coma; adrenocortical insufficiency. Pregnancy and lactation. Hypersensitivity, cardiac failure, recent MI, CHF. IDDM, severe infection,acute or chronic metabolic acidosis with or without coma, stress, trauma, severe impairment of thyroid function, dehydration, acute or chronic alcoholism. Special Precautions: Overdosage,elderly,dietary errors, mild to moderate renal and hepatic disorders. Impaired alertness. Avoid alcohol. Carefully monitor blood-glucose concentration.
Special caution in patient with G6PD deficiency, autonomic neuropathy, thyroid or adrenocortical insufficiency; Patient exposed to stress (e.g. fever, trauma, infection, surgery); Mild to moderate hepatic or renal impairment; Elderly, debilitated and malnourished patients; Pregnancy and lactation.Monitor blood glucose, glycosylated Hb level, signs and symptoms of hypoglycaemia.
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