Can cause angioedema of the face and tongue, glottis; intestinal angioedema; Cholestatic jaundice; Asthenia/fatigue, headache, dizziness, hypotension, persistent and non-productive cough, syncope, nausea, vomiting, vertigo, abnormal kidney function, and diarrhoea; Hyperkalemia; Anaemia, neutropenia/agranulocytosis, pancytopenia, leukopenia, thrombocytopenia. Increased BUN and serum creatinine levels.
Contraindicated in patients with history of angioedema . Concomitant use with aliskiren in patients with diabetes or renal impairment; Pregnancy and lactation.
Special caution to be taken in patients with bilateral renal artery stenosis or a single kidney with unilateral renal artery stenosis; at risk for hypotension (e.g. patients with volume or salt depletion); aortic or mitral valve stenosis; Renal and hepatic impairment.
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