Leucovorin calcium

What Are The Uses Of Leucovorin calcium?

Leucovorin calcium, also known as folinic acid, is used to reduce or diminish:

• The toxic effects of high dose methotrexate therapy in osteosarcoma (a type of bone cancer)
• The toxicity of inadvertent overdose of folic acid antagonists
• The effects of impaired methotrexate elimination

It is also used for:

• The treatment of megaloblastic anaemias due to the folic acid deficiency in those cases where oral therapy is not feasible.
• Prolonging the survival in the palliative treatment of patients with advanced colorectal cancer (in combination with 5-fluorouracil).

What Are The Side Effects Of Leucovorin calcium?

Some of the common side-effects of Leucovorin calcium are:

• Urticaria
• Nausea                

What Are The Contraindications Of Leucovorin calcium?

Please inform your doctor if you have any of the following conditions:

• Allergy to folic acid or folinic acid
• Vitamin B12 deficiency