CLAIRMEL 250 MG TABLET has the following salts in its composition
1) Tranexamic Acid
Uses Of CLAIRMEL 250 MG TABLET
Tranexamic Acid is used for:
- Managing certain types of bleeding disorders like haemophilia.
- Controlling bleeding from tooth extraction.
- Other high-risk bleeding conditions like after surgery or injury Heavy menstrual bleeding
- Heavy nosebleeds
Side Effects Of CLAIRMEL 250 MG TABLET
Common side-effects of Tranexamic Acid are:
- Nasal sinus problems
Contraindications Of CLAIRMEL 250 MG TABLET
Pl. inform your doctor if you have/ had any of the following conditions:
- Blood clot in any part of the body
- Color vision problems
- Bleeding in brain
- Abnormal uterine bleeding is the irregular bleeding from longer or heavier uterus than usual. After being tested through a number of different tests, various treatments recommended by the doctor could be giving hormones like progesterone and estrogen. Hysteroscopy could be done to remove polyps or fibroids.
- Surgery like endometrial ablation or hysterectomy is done when other treatments fail to work.
Haemophilia is a medical condition in which there is an aberration in a person’s ability to coagulate blood. In layman’s terms, people who suffer from haemophilia are often referred to as having a "bleeding tendency." Haemophilia is the commonest disorder of coagulation and is an inherited condition. There are two types of Haemophilia: Haemophilia A and Haemophilia B.
Coagulation of blood is controlled by different clotting factors found in the blood, as well as blood platelets. Haemophilia A is due to a deficiency in factor VIII of the clotting factors. Haemophilia B is due to a deficiency in factor IX.
Bleeding or injury leads to the trigger of a complex clotting cascade. Platelets in the blood initially arrive at the site of injury, as an acute response to achieve haemostasis. Clotting factors are involved in the subsequent response to trauma, as platelet binding causes activation of the coagulation pathway. The coagulation cascade has two pathways, extrinsic and intrinsic, which both lead to the end goal of fibrin formation. Fibrin forms a mesh-like structure that assists blood clot formation, as other factors involved in blood clotting can adhere to this framework.
Calcium, Vitamin K and phospholipids also contribute to the clotting pathway.
The symptoms due to haemophilia may differ, depending on the severity. Some may only experience mild episodes, while others may experience life-threatening haemorrhages.
Mild haemophilia is classified when there is more than five percent of clotting factors present and active, moderate haemophilia is when there is between one and five percent of factors present, and severe haemophilia occurs when there is less than one percent of the clotting factor present.
Haemophilia is treated with factor replacement or FFPs (Fresh Frozen Plasma).
Bleeding nose is also known medically as epistaxis. Nosebleeds occur commonly among children and adults and are often not a cause for alarm and do not indicate any major health issue. However, in some rare cases, it can be life-threatening. Frequent nosebleeds may be a symptom that indicates a more serious health condition.
Nosebleeds are classified as anterior or posterior nosebleeds.
- Anterior Nosebleed: The frontal portion of the nose contains several delicate blood vessels and in the case of anterior nosebleeds, the bleeding occurs from the wall present between both the nostrils. Anterior nosebleeds are common in children and can be treated easily at home.
- Posterior Nosebleed: In this case, the blood originates further behind and higher in the area where the branches of the artery supply the blood to the nose, which is why posterior nosebleeds are heavier. This kind of nosebleeds are more serious and require medical attention. They occur more commonly in adults.
Symptoms Treated With CLAIRMEL 250 MG TABLET
- Irregular, heavy and more frequent mensuration.
What Are The Symptoms Of Haemophilia
Haemophilia is usually suspected when a person has a prolonged bleeding time after a minimal event such as drawing blood, teeth extraction or a superficial abrasion that doesn’t heal. Trauma may also precipitate an abnormal bleeding response, e.g. bleed into a joint after a minor fall.
Internal or external haemorrhages range from mild to moderate bleeding episodes, depending on the severity of haemophilia that a person has. Haemophilia usually presents in childhood, and if severe, may present within the first two years of life.
Common symptoms include:
- Prolonged bleeding after tooth extraction, or bleeding from gums in teething infants
- Haemarthrosis (bleeding into joints) after minor traumas. Recurrent episodes of haemarthrosis may lead to progressive destruction and deformities of joints, and eventually, secondary osteoarthritis may occur.
- Haematomas in muscles may occur and can predispose to compartment syndrome (potential muscle and nerve cell death due to increased pressures in the soft tissue "compartments")
- Haematuria (blood in the urine)
- Prolonged bleeding after surgery
- Severe bleeding episodes can lead to intracranial haemorrhage (bleeding in the brain). This may present with headaches, nausea, projectile vomiting, neurological fallouts or altered level of consciousness.
- Gastrointestinal bleeding may lead to blood in stools
The primary symptom of nosebleed is when there is light to heavy bleeding from the nose. The blood comes out through either one of the nostrils and typically, only one of the nostrils is affected. Sometimes, the blood may run into the throat or can be swallowed and this can cause nausea or vomiting. Excessive loss of blood due to a nosebleed is not very common, but can cause:
- Palpitations, shortness of breath
- Dizziness, confusion
- Fainting, light-headedness
- Turning pale
Causes of diseases where CLAIRMEL 250 MG TABLET is used
- Changes in hormone level, growths in the uterus (fibroids), polycystic ovaries or clotting problems can cause AUB.
What Are The Causes Of Haemophilia
Haemophilia is a genetic, sex-linked disorder that carried by the X-chromosomes. X-chromosome linkage implies that mainly males are affected, as they have only one X-chromosome and one Y-chromosome.
Females can be the genetic “carriers" of haemophilia, as they have two X chromosomes, and an additive healthy X-chromosome may minimise the effects of the X-gene carrying haemophilia. It is estimated that about one-third of carrier females may have mild bleeding tendencies although most female carriers are asymptomatic. A female may have haemophilia if her mother is a carrier, and her father has haemophilia- thus receiving two abnormal X-genes.
A mother with a carrier gene has 25% chance of affecting her son, and 25% chance of her daughter inheriting the gene.
Haemophilia A occurs in about five to ten percent of cases. Different genetic mutations give rise to haemophilia A. Haemophilia B is more common, and occurs in eighty percent of cases.
Anterior nosebleeds may be caused due to:
- Picking the nose often and if the inside of the nose is tender and irritated, trauma to the nose.
- Sinusitis or inflammation of the sinus cavity.
- Blowing the nose often when having a cold, nasal allergy or flu.
- Irritation and tenderness of the nose due to viral infection.
- Deviated septum (the wall between the 2 nostrils deviates).
- Extremely hot or dry climate, high altitude causing dryness in the nose.
- Medications such as NSAIDs, blood thinners, etc.
- Liver disease that interferes with the blood clotting.
- Use of illegal drugs like cocaine.
Posterior nosebleeds may be caused due to:
- High blood pressure, calcium deficiency
- Nasal surgery, exposure to chemicals
- Diseases of the blood like leukemia or hemophilia, tumors
- Broken nose, foreign body stuck in nose
- Low platelet count (thrombocytopenia)
- Osler-Weber-Rendu disease (rare genetic disorder of blood vessels)
- Aortic coarctation (narrowing of the aorta)
- Glomerulonephritis (acute inflammation of the kidney)
- Stuart-Prower factor deficiency (Factor X deficiency) protein deficiency
- Ebola, Von Willebrand disease
- Deficiency of factor II, V, or VII (rare conditions affecting blood clotting)
- Idiopathic thrombocytopenic purpura (blood does not clot properly)
- Rheumatic fever
- Liver cirrhosis (due to prolonged exposure to toxins)
- Leishmaniasis (disease transmitted by the sand fly)
- Celiac disease - an allergy to gluten.
Worst Foods With CLAIRMEL 250 MG TABLET
- Avoid cheese and saturated meat products
- Right balance of estrogen and progesterone in woman’s body is extremely important. If you have estrogen dominance and progesterone deficiency, you should avoid foods that increase estrogen levels. Foods to avoid in such condition are: Soy, sugar, dried fruits especially dried apricots, dates, and prunes, flax seeds, sesame seeds etc.
What Are The Worst Foods For Haemophilia
Foods that have a natural anticoagulant effect should be avoided. These include:
- Turmeric, Cinnamon, Cayenne pepper
- Vitamin E containing foods: Avocados, sunflower seeds, peanuts, Brazilian nuts
- Fatty fish high in EPA, which has a mild anticoagulant effect should be used in moderation.
- Avoid greasy, spicy and oily foods as they worsen the condition of nosebleeds.
- One reason why kids get nosebleeds is due to the presence of salicylates in certain fruits and fruits juices like grapes, apples, plums, peaches, tomatoes, etc. Avoid these fruits and opt for other low-salicylate fruits such as pineapples, pears, bananas, dates, figs, mangoes, etc.
- Avoid caffeinated drinks like tea, coffee, etc. as they cause the nosebleed to worsen.
- Avoid drinking alcohol as it causes dehydration in the body and aggravates the nosebleed.
Do's With Usage of CLAIRMEL 250 MG TABLET
- Rest and Destress as high stress is a direct cause of low progesterone
- Keep a check on your weight
- Eating small and frequent meals helps in managing Premenstrual Syndrome
What Are The Things One Should Do To Manage Haemophilia
What Are The Things One Should Do To Manage Heavy Nose bleeding
If you are having heavy nosebleeds:
- Pinch the soft part of your nose firmly and try to breathe via the mouth.
- Don’t lean backward. Instead, lean forward to stop the blood from getting into the throat and sinus, as this can cause gagging and inhalation of the blood.
- Sit straight so that your head is at a higher level than the heart. This helps to reduce the blood pressure and lessens bleeding.
- Apply an ice pack or cold compress to the nose and cheek areas to soothe it.
- Apply some lubricating ointment or creams like petroleum jelly inside the nose to prevent dryness and irritation.
- If you live in high altitudes or the climate is very dry, make use of a humidifier.
Dont's With Usage Of CLAIRMEL 250 MG TABLET
What Are The Things One Should Avoid To Manage Haemophilia
- Be cautious before using any herbal medicine or supplement, as they often influence coagulation of blood (thinning or thickening blood)
- Anti-inflammatory medications should be avoided due to their platelet inhibiting ability. This includes NSAIDs such as Aspirin and Ibuprofen.
- Contact sports should be avoided due to the increased risk of bleeding into tissues.
What Are The Things One Should Avoid To Manage Heavy Nose bleeding
- Avoid strenuous activity for a few days after you suffer from a nosebleed.
- Avoid picking your nose.
- Avoid blowing the nose frequently or too hard.
Other Useful Tips With Usage OfCLAIRMEL 250 MG TABLET
- Lifestyle changes like maintaining body weight, regular exercise and distressing is recommended.
Supplements that decreases blood clotting and should be avoided include:
- Gingko Biloba
- Vitamin E-containing supplements
Some home remedies you can follow to stop nosebleeds or prevent them from occurring are:
- Apple cider vinegar is extremely effective for stopping a nosebleed very quickly. It helps to seal the broken blood vessels and also protects the body from too much of blood loss. Soaking a small ball of cotton in apple cider vinegar and placing it into the bleeding nostril can help to stop the bleeding quickly. You can also use white vinegar if you don’t have apple cider vinegar.
- Apple cider vinegar is also effective in preventing nosebleeds from occurring frequently. Mix 2 teaspoons of apple cider vinegar in warm water and drink it thrice in a day.
- Cayenne is very effective in stopping nosebleeds. It works regulates the pressure of the blood flow and also works as a cell stimulant, thereby helping in quick blood coagulation. Adding a teaspoon of cayenne powder to a cup of warm water can help to stop a nosebleed.
- Onion has excellent clotting properties and is very effective in stopping nosebleeds. Placing a slice of onion under the nose and inhaling the fumes can help to stop nosebleed within minutes. You can also put 2-3 drops of fresh onion juice into the nostril to stop bleeding.
- A very common cause of nosebleeds is due to dryness during winter. You can moisturize and soothe the nasal membranes by using saline water. Simply add a pinch of salt to half a cup of warm water and put this solution into your nostrils to moisten the inner lining. You can also use nasal sprays that are available in the market.