It can cause dependence, withdrawal symptoms; nausea, vomiting, constipation, drowsiness, confusion, difficulty in micturition, ureteric or biliary spasms, urinary retention, dry mouth, dizziness, sweating, facial flushing, headache, vertigo, bradycardia, oedema, postural , vertigo, restlessness, mood changes, decreased libido or potency, raised intracranial pressure, muscle rigidity, visual disturbances.
It is contraindicated in case of respiratory depression; obstructive airway disease; acute and severe asthma attack; presence or suspicion of paralytic ileus, acute ulcerative colitis, antibiotic-associated colitis; comatose patients; acute alcoholism. Patients with head injury, raised intracranial pressure; in Children <1 yr.
Special caution is required in case of hypothyroidism, adrenocortical insufficiency; prostatic hyperplasia, hypotension, shock, inflammatory or obstructive bowel disorders, myasthenia gravis; Renal and hepatic impairment; Pregnancy and lactation ; Elderly or debilitated patients; it may impair ability to drive or operate machinery.
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