Dryness of mucous membranes/ skin with scaling, fragility, erythema, cheilitis, pruritus, epistaxis, conjunctivitis, dry sore mouth . Corneal opacities, dry eyes, visual disturbances, skeletal hyperostosis and musculoskeletal symptoms. Elevation of serum triglycerides, LFTs, ESR and blood glucose. Hair thinning, photosensitivity, changes in skin pigmentation, paronychia. GI disturbances, hepatitis. Headache, drowsiness, sweating, mood changes, psychotic symptoms, depression, suicidal tendencies, benign intracranial hypertension, seizures. Vasculitis, hypersensitivity reactions, IBS. potentially fatal reactions include anaphylaxis; Haemorrhagic pancreatitis
Special precaution in case of preexisting or predisposition to hypertriglyceridaemia ; Monitor triglyceride levels; Monitor blood lipids and LFTs at weekly or bi-weekly intervals; Monitor blood glucose in known or suspected Diabetes Mellitus patients. Caution in history of psychiatric disorder; May impair night vision; Avoid wax epilation and skin resurfacing procedures for at least 6 mth; Avoid prolonged exposure to UV light or sunlight; Discontinue if hearing impairment, abdominal pain, rectal bleeding, severe diarrhoea or adverse ocular effects occur. Patient should not donate blood during therapy and for at least 1 mth following drug discontinuation.
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