Constipation, diarrhoea, nausea/ vomiting, oesophagitis, flatulence, gastritis, heartburn/acid reflux, epigastric discomfort, oral ulcer, alveolar osteitis, fluid retention, dizziness, headache, palpitations, arrhythmia, HTN, asthenia/fatigue, flu-like disease, bronchospasm, ecchymosis, increased ALT and AST. Potentially Fatal side effect include Stevens-Johnson syndrome, exfoliative dermatitis and toxic epidermal necrolysis; upper GI ulceration, perforation and bleeding.
Contraindicated in hypersensitivity; Patient with inflammatory bowel disease, active GI ulceration or bleeding, moderate to severe heart failure ; ischaemic heart disease, peripheral arterial disease, uncontrolled HTN ; acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or allergic-type reactions after taking aspirin, NSAIDs including COX-2 inhibitors; in case of Children and adolescent <16 yr; Lactation.
Cautious use in patient with significant risk factors for CV disease e.g. HTN, hyperlipidaemia and DM; pre-existing oedema; history of left ventricular dysfunction, cardiac failure; history of upper GI ulceration, perforation and bleeding; Mild to moderate hepatic impairment; in Elderly; Pregnancy. Monitoring Parameters like BP before treatment, within 2 wk after initiation of therapy and periodically thereafter.
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